ModifyMeds.caTable of oral medications that cannot be divided or crushed
The following table presents oral drugs that should not be divided or crushed. We tried to provide the latest and most accurate information possible. Given the huge amount of drugs on the market, it is virtually impossible to have a complete list. The medications that are not on this list are not necessarily possible to divide or crush. Due to new ongoing studies or case reports, information considerer accurate today, may be obsolete next month. When in doubt, it is suggested to check with the manufacturer, and then to judge according to the physicochemical characteristics of the drug form and the clinical situation. One must remember that there are always alternatives, in another form or in the same class products, which can be used safely and are recognized. The options in the table are only suggestions and not a substitute for clinical judgment of the pharmacist or health professional. The frequency of administration must be adjusted if the alternative is not a sustained release form.
We encourage drug manufacturers and health professionals to send us any information that would complement, improve and keep updating this list for future publications.
Please send any suggestions or comments to peter.dvorak@videotron.ca
Latest database update: June 1st 2025
| DRUG'S NAME | DIVIDE? | CRUSH TABLET? OPEN CAPSULE? | ALTERNATIVES | COMMENTS |
|---|---|---|---|---|
| 5-ASA (Novo®) enteric-coated tablet | NO | NO | Dissolves in terminal ileum | |
| AAS (generic) enteric-coated tablet | NO | NO | Aspirin® or Asaphen® 80mg chewable tablets | |
| Absorbica LD® capsule | NO | NO | Mucous membrane irritant. Swallow what. Do not chew. Photosenstive. | |
| Abstral® sublingual tablet | NO | NO | Sublingual use. Do not cut chew or crush the tablet. | |
| Acarizax® sublingual tablet | NO | NO | Sublingual use | |
| Accutane Roche® capsule | NO | NO | 10 mg capsules much smaller than 40mg. | Mucous membrane irritant. Do not chew. Photosenstive. |
| Acid valproic (generic) capsule | NO | NO | Depakene® or generic liquid suspension | Mucous membrane irritant. Swallow whole. Do not chew. |
| Actonel® tablet | NO | NO | Fosamax® oral solution 70mg/75ml (discontinued may 2011) | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Adalat® XL® osmotic tablet | NO | NO | Amlodipine (Norvasc®) (Same family) may be crushed. | Severe overdose risk if tablet modifyed!! Swallow whole. |
| Adalat® XL® Plus extended-release tablet | NO | NO | Amlodipine (Norvasc®) (same family) and Aspirin® 81mg chewable tablet | Severe overdose risk if tablet modifyed!! Swallow whole. |
| Adderall XR® extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce. Do not divide the content of the capsule. | |
| Advagraf® extended-release capsule | NO | NO | Prograf® capsule | |
| Advicor® extended-release tablet | NO | NO | Noninterchangeable for regular niacin tablet. | Formulation contents immediate release lovastatin and extended release niacine. |
| Advil® tablet, capsule, gelcap | See alternative | See comment | Prefer oral suspension or chewable tablet if dysphagy or need to divide tablet | Taste may be unacceptable to patient. |
| Afinitor® tablet | NO | NO | Mucous membrane irritant. Do not chew or crush. | |
| Agenerase® capsule | NO | NO | Agenerase® oral solution bioavailability 14% inferior compared to capsules and toxicity due to high content o propylene glycol. | Swallow capsule whole |
| Aggrenox® extended-release and immediate release capsule | NO | NO | Capsule may be opened, ASA tablet chewed and dipyridamole pellets sprinkled on applesauce. | |
| Akeega® tablet | NO | NO | Swallow whole do not cut crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Akynzeo® capsule | NO | NO | Swallow whole capsule, do not open. | |
| Aldactazide® tablet | See comment | See comment | Compound of spironolactoneHCTZ 2.5mg/ml | The 50 mg tablet is scored.Bitter taste of spironolactone may be unacceptable to patient if crushed. |
| Aldactone® tablet | See comment | See comment | Compound of spironolactone 25mg/ml. | The 100 mg tablet is scored.Bitter taste of spironolactone may be unacceptable to patient if crushed. |
| Alecensaro® capsule | NO | NO | Swallow whole capsule | |
| Alendronate (generic) tablet | NO | NO | Fosamax® oral solution 70mg/75ml (discontinued may 2011) | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Alfuzosin (generic) extended-release tablet | NO | NO | Matrix layer containing afuzosin between 2 inactive layers. | |
| Alkeran® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Allegra D® sustained-release two layer tablet | NO | NO | Allegra®12h plus pseudoephedrin 60mg tablet or sirup 30mg/5ml (Pms®) | The layer containing pseudoephedrine is extended release (matrix) |
| Altace®HCT tablet | YES | NO | Altace® caspule plus hydrochlorothiazide 12.5mg o 25mg tablet | |
| Alunbrig® tablet | NO | NO | Swallow whole do not cut crush or chew | |
| Amantadine (generic) capsule | NO | Prefer alternative | Symmetrel® oral solution 50mg/5ml | |
| Anandron® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Andriol® capsule | NO | NO | Androgel® or Androderm® | Do not chew capsule |
| Ansaid® film-coated tablet | NO | NO | Crushed sucked or chewed tablets may cause oropharyngeal irritation. | |
| Aptiom® tablet | YES | YES See comment | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce. Has to be taken in the 10 following minutes. | |
| Aptivus® capsule | NO | NO | Do not alter capsule. Oil emulsion within spheres and unacceptable taste . | |
| Arava® tablet | NO | YES See comment | Immunomodulator manipulate with caution. Swallow whole. Tératogenic. Can be crushed if no other possibility available. | |
| Aricept RDT® rapidly disintegrating tablet | NO | See comment | Tablet dissolves on the tongue. Crumbly tablet. | |
| Arimidex® tablet | See comment | YES See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Aromasin tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Arthrotec® enteric-coated bi-layer tablet | NO | NO | The core of the tablet contains diclofenac and is enteric-coated. | |
| Asacol® enteric-coated tablet | NO | NO | Pentasa® but produces effect on small intestine and colon. | Dissolves in terminal ileum |
| Asaphen®EC enteric-coated tablet | NO | NO | Asaphen® chewable tablet | |
| Aspirin®EC enteric-coated tablet | NO | NO | Aspirin® 80mg chewable tablet | |
| Ativan® sublingual tablet | NO | NO | Ativan® tablet | Sublingual tablet has to be placed under tongue |
| Atomoxetine (generic) capsule | NO | NO | Swallow whole. Capsule content irritant for skin eyes and mucosa. | |
| Aubagio® tablet | See comment | See comment | Immunomodulator. Take precautions applied to cytostatic drugs. | |
| Avelox® tablet | YES | YES See comment | Taste may be unacceptable to patient. Do not chew. Coating masks taste. Can be crushed and mixed with applesauce. | |
| Avodart® capsule | NO | NO | Teratogenic and may be absorbed by skin. Women and children should not manipulate capsule. Mucous membrane irritant. | |
| Ayvakyt® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Azathioprine (generic) tablet | See comment | See comment | Compound of azathioprine lOmg/ml or 50mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. Tablet is scored. |
| Balversa ® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Swallow whole. | |
| Bellergal®Spacetabs tablet | YES | NO | ||
| Betaloc® Durules® slow release tablet | YES in two | NO | Betaloc® regular tablet or generic | |
| Bezalip® SR extended-release tablet | NO | NO | Pms-bezafibrate 200mg tablet (2-3 times daily) or fenofibrate capsule (same family) | |
| Biaxin®XL extended-release tablet | NO | NO | Biaxin® regular tablet or Biaxin® oral suspension (twice a day) | |
| Bicalutamide (generic) tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Biltricide® tablet | YES | See comment | Do not chew bitter taske can cause nauseas and vomiting. | |
| Biphentin® controlled release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, ice cream or yogurt. | |
| Biquin Durules® extended-release tablet | NO | NO | ||
| Bisacodyl (generic) enteric-coated tablet | NO | NO | Bisacodyl rectal suppository | Inactivated by stomach acid if coating damaged. |
| Bonefos® capsule | NO | NO | Crushed sucked or chewed tablets may cause oropharyngeal irritation. | |
| Bosulif® tablet | NO | NO | Do not cut, crush, chew or try to dissolve. Antineoplasic. Take precautions applied to cytostatic drugs. | |
| Braftovi® capsule | See comment | See comment | Antineoplasic. Take precautions applied to cytostatic drugs. | |
| Brivlera® tablet | NO | NO | Swallow whole. Do not cut, crush or chew tablet. | |
| Brukinsa® capsule | NO | NO | Swallow whole. Do not open, crush or chew capsule. | |
| Bupropion SR (generic) sustained-release tablet | See comment | NO | Matrix tablet theoretically can be divided in 2 and taken immediately. | |
| Buscopan® tablet | NO | See comment | Photosensitve and bitter taste. Swallow whole tablet. | |
| Bylvay® capsule | NO | YES see comment | Capsule may be opened and the contents taken without crushing and chewing mixed with soft food or liquid. | |
| Calquence® capsule | NO | NO | Antineoplasic. Take precautions applied to cytostatic drugs. Swallow whole. Do not open, crush or chew capsule. | |
| Camzyos® capsule | NO | NO | Swallow whole. Do not open, crush or chew capsule. | |
| Campral® delayed release tablet | NO | NO | ||
| Caprelsa® tablet | NO | NO | Dissolve in 50ml of water and drink immediately. Antineoplasic. Take precautions applied to cytostatic drugs. | |
| Carbamazepine CR (generic) controlled-release tablet | YES in two | NO | Tegretol® or generic chewable tablet (1OOmg ou 200mg) or oral suspension (100mg/5ml) | |
| Carbometyx® tablet | NO | NO | Antineoplastic. Swallow whole. Do not cut crush or chew tablet. | |
| Cardizem® tablet | See comment | NO | Compound of diltiazem 12mg/ml | 60mg tablet is scored. Do not chew or crush. |
| Cardizem® CD controlled delivery capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, or in a glass of water and taken immediately. | |
| Carter, Little pills enteric-coated tablet | NO | NO | Bisacodyl rectal suppository | Inactivated by stomach acid if coating damaged. |
| Casodex® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Catena® tablet | NO | NO | Do not chew tablet. | |
| Cedocard® SR extended-release tablet | NO | NO | ||
| CeeNU® capsule | NO | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Ceftin® tablet | See comment | See comment | Ceftin® oral suspension | Bitter taste may be unacceptable to patient. |
| Cefuroxime (generic) tablet | See comment | See comment | Ceftin® oral suspension | Bitter taste may be unacceptable to patient. |
| Cellcept® tablet and capsule | NO | NO | Cellcept® oral suspension 200mg/ml | Immunosuppressant. carcinogenic potential if contact with skin or inhaled. Take precautions applied to cytostatic drugs. |
| Celsentri® tablet | YES | YES See comment | Do not chew tablet. | |
| Cerdelga®capsule | NO | NO | Do not open, chew or crush capsule | |
| Chloroquine (generic) tablet | YES | See Comment | Bitter taste if chewed or crushed. | |
| Cipralex® MELTZ | NO | NO | Orodispersible tablet | |
| Cibinqo® tablet | NO | NO | Swallow whole. Do not cut, crush or chew tablet. | |
| Ciprofloxacine (generic) tablet | YES See comment | YES See comment | Cipro® oral suspension. Do not chew microgranules. | Bitter taste may be unacceptable to patient. |
| Cipro® tablet | YES | YES See comment | Cipro® oral suspension. Do not chew microgranules. | Bitter taste may be unacceptable to patient. |
| Cipro®XL extended-release tablet Ciprofloxacin XL (generic) tablet | NO | NO | Cipro® oral suspension. Do not chew microgranules. | 35% of dose is immediate release, 65% is a slow release matrix. |
| Clarithromycine®XL extended-release tablet | NO | NO | Biaxin® regular tablet or Biaxin® oral suspension (twice a day) | |
| Claritin® rapid dissolve tongue tablet | NO | NO | Dissolves on tongue. | |
| Claritin®Allergy+Sinus modified-release tablet | NO | NO | Claritin® rapid dissolve tablets and pseudoephedrine 60mg tablets or oral solution 30mg/5ml (Pms®) | Bilayer tablet. 5mg of loratadine and 60 mg of pseudoephedrine in coating and 60 mg of pseudoephedrine in extended release core. |
| Claritin®Allergy+Sinus Extra Strength modified-release tablet | NO | NO | Claritin® rapid dissolve tablets and pseudoephedrine 60mg tablets or oral solution 30mg/5ml (Pms®) | Bilayer tablet. 5mg of loratadine and 60 mg of pseudoephedrine in coating and 60 mg of pseudoephedrine in extended release core. |
| Clarus® capsule | NO | NO | Mucous membrane irritant. Do not chew. Photosenstive. | |
| Clasteon® capsule | NO | NO | Crushed sucked or chewed tablets may cause oropharyngeal irritation. | |
| Codeine Contin® controlled-release tablet | See comment | NO | Codeine tablet or oral solution | Except for 50mg, can be splitted in 1/2 only. Risk of fatal overdose if chewed, crushed or disolved. |
| Colace® capsule | NO | See comment | Colace® or generic oral drops or oral solution. | Taste may be unacceptable to patient. |
| Colestid® tablet | NO | NO | Colestid® granules (mixed with a liquid) | Risk of oesophagal spasm if tablet crushed. |
| Complera® tablet | YES | NO See comment | Bioavailability of rilpivirine decreased up to 50% if tablet crushed. | |
| Constella® capsule | See comment | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce or 30ml of bottled water and taken immediately. | |
| Contrave® extended-release tablet | NO | NO | Swallow whole. Do not cut crush nor chew. | |
| Cotazym® capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with food or drink. | |
| Cotellic® tablet | NO | NO | Antineoplasic. Take precautions applied to cytostatic drugs. | |
| Covera-HS® controlled onset extended-release tablet( Discontinued in Canada) | NO | NO | Other formulation of verapamil | Do not alter tablet. |
| Cozaar® tablet | YES | YES See comment | Bitter taste may be unacceptable to patient. | |
| Creon® Minimicrosphères capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing. mixed with food or drink. | |
| Cresemba® capsule | NO | NO | Do not open, disolve, chew or crush capsule. | |
| Crixivan® capsule | NO | See comment | Capsule may be opened and mixed with fruit sauce or acid beverage (Coca-Cola). taste may be unacceptable to patient. | |
| Cyclosporine (generic) capsule | NO | NO | Neoral® oral solution | Immunomodulator. Take precautions applied to cytostatic drugs. |
| Cymbalta® delayed-release capsule | NO | NO | Manufacturer suggests not to open capsule, but product stays stable 2 hours if mixed with applesauce or apple juice. | |
| Cytovene® capsule | NO | NO | Potentially carcinogenic and teratogenic. Skin irritant. Take precautions applied to cytostatic drugs. | |
| Cytoxan® tablet | See comment | See comment | Oral solution can be prepared using the powder for injection. See Procytox. | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Daurismo® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| DDAVP® Melt sublingual tablet | NO | NO | Melts when under tongue. | |
| Depakene® capsule | NO | NO | Depakene® oral solution 250mg/ml or generic | Swallow whole. Mucous membrane irritant. The 500mg tablet is enteric coated. |
| Desipramine (generic) tablet | NO | See comment | Taste may be unacceptable to patient. | |
| Desyrel® tablet | YES | See comment | Compound of trazodone lOmg/ml | Do not chew. Taste may be unacceptable to patient. |
| Detrol® LA extended-releasecapsule | NO | NO | Capsule may be opened and the contents mixed with soft food taken without crushing and chewing. | |
| Dexedrine Spansule® sustained-release capsule | NO | NO | Capsule may be opened and the contents mixed with soft food taken without crushing and chewing. | |
| Dexilant® enteric-coated capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce. | |
| Diacomit® capsule | NO | NO | Diacomit® oral powder | Do not crush or chew the capsule. |
| Diamicron®MR modified-release tablet | YES the 60mg tablet only | NO | Diamicron® regular tablet 80mg (twice a day) | |
| Dicetel® tablet | NO | NO | Mucous membrane (oesophagus) irritant | |
| Diclectin® delayed-release tablet | NO | NO | ||
| Diclofenac E (generic), Diclofenac+misoprostol enteric-coated tablet | NO | NO | Voltaren® or diclofenac suppository | |
| DiclofenacSR (generic) slow-release tablet | NO | NO | Voltaren® or diclofenac suppository or other anti inflammatory | |
| Didrocal® (etidronate) tablet | YES | NO | Mucous membrane (oesophagus) irritant. Can be dissolved in a glass of water. Drink immediately, followed by another glass of water. | |
| Didronel® tablet | YES | NO | Mucous membrane (oesophagus) irritant. Can be dissolved in a glass of water. Drink immediately, followed by another glass of water. | |
| Diflunisal (generic) tablet | NO | NO | Mucous membrane irritant. | |
| Dilantin® extended-release capsule | NO | NO | Dilantin® Infatabs 50mg or suspension 125mg/5ml | |
| Diltiazem (generic) tablet | See comment | NO | Compound of diltiazem 12mg/ml | 60mg tablet is scored. Do not chew or crush. |
| Diltiazem HCL ER (generic) and Diltiazem T (generic) extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, or in a glass of water and taken immediately. | |
| Diltiazem SR and CD (generic) controlled delivery capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, or in a glass of water and taken immediately. | |
| Ditropan XL® extended-release tablet | NO | NO | Ditropan® regular tablet or Oxybutinin® syrup 5mg/5ml ou Oxytrol® Transdermal patch.. | Osmotic tablet do not modify |
| Divalproex (generic) enteric coated tablet | NO | NO | ||
| Docusate (generic) sodique et calcique capsule | NO | See comment | Colace® or generic oral drops or syrup. | Taste may be unacceptable to patient. |
| Donepezil ODT generic orally disintegrating tablet | NO | See comment | Tablet melts on tongue. Crumbly tablet. | |
| Doxycycline (generic) tablet and capsule | NO | NO | Compound of doxycycline 5mg/ml | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Duavive® modified release tablet | NO | NO | Swallow whole. Do not cut crush chew or dissolve in mouth. | |
| Dulcolax® enteric-coated tablet | NO | NO | Dulcolax® suppository | Active ingredient inactivated by gastric acidity |
| Dutasteride generic capsule | NO | NO | Teratogenic potential. May be absobed through skin. Mucous membrane irritant. | |
| Duralith® extended-release tablet (Discontinued in 2007) | YES | NO | Carbolith® capsule or equivalent. Lithium citrate syrup 300mg/5ml (Pms®). | 5ml of lithium citrate syrup equals to 300mg of lithium carbonate. |
| Durela® extended-release capsule | NO | NO | A part of capsule is extended release and other part immediate release. Do not open or modify. | |
| Effexor®XR extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce. | |
| Effient® tablet | NO See comment | NO See comment | In the situation of hospital care: may be cut or crushed and administered immediately. | |
| Eltor® 120 extended-release tablet | NO | NO | Pseudoephedrine tablet 60mg or syrup 30mg/5ml (Pms®) | |
| Emcyt® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Emtriva® capsule | NO | See comment | Content of capsule may be dissolved in a glass of water or orange juice. Drink immediately. | |
| Enablex® extended-release tablet | NO | NO | ||
| Entex®LA extended-release tablet | YES | NO | Pseudophedrine tablet 60mg or syrup 30mg/5ml (Pms®) and guaifenesine syrup. | |
| Entresto® tablet | See comment | See comment | According to European reference (HUG) and galenic formulation may be cut or crushed. The 2 active ingredients are equally distributed in the tablet. Manufacturer suggests not to alter tablet. | |
| Entocort® controlled ileal release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce. | |
| Epival® enteric-coated tablet | NO | NO | ||
| Epuris capsule | NO | NO | Swallow whole capsule. Mucous membrane irritant. Photosensitive. | |
| Erivedge® capsule | NO | NO | Swallow whole do not open chew or crush. | |
| Erleada ® tablet | NO | NO | Swallow whole do not open chew or crush. | |
| Eryc® delayed release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce or food. | |
| ErythromycineE-C (generic) enteric-coated capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce or food. | |
| Escitalopram ODT (generic) tablet | NO | NO | Orodispersible tablet | |
| Esomeprazole (generic)delayed release tablet | NO | NO | Nexium® tablet may be dissolved in a glass of water. Drink immediately. | |
| Etidronate (generic) tablet | See comment | NO | Mucous membrane (oesophagus) irritant. Can be dissolved in a glass of water. Drink immediately, followed by another glass of water. | |
| Euflex® tablet | Yes but See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. Tablet is scored. | |
| Evista® tablet | NO | NO | Taste may be unacceptable to patient. Teratogenic. | |
| Evotaz® tablet | NO | NO | Swallow whole do not cut, chew or crush tablet. | |
| Exelon® capsule | NO | NO | Exelon® oral solution 10mg/5ml ou Exelon® transdermal patches 5mg or lOmg | |
| Exemestane generic tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Exjade® dispersible tablet | NO | NO | Tablet has to be dissolved in water. orange or apple juice. | |
| Factive® tablet | YES | NO | Swallow whole | |
| Fampyra® extended-release tablet | NO | NO | Do not cut, crush, chew or alter. Convulsions risk if tablet is modified. | |
| Felodipine (generic) extended-release tablet | NO | NO | Other medication of same family as Norvasc® | |
| Femara® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Fentora® sublingual tablet | NO | NO | Sublingual use only. | |
| Ferrous fumarate or sulfate modified-release tablet or capsule | NO | NO | Oral solutions of sulfate or fumarate available commercially | Swallow whole do not cut open chew or crush. |
| Flomax® sustained-release capsule (discontinued in 2007) | NO | NO | Do not crush or chew the granules in capsule. | |
| Flomax®CR controlled release tablet | NO | NO | Generic tamsulosin capsule | |
| Florazole ER extended-release tablet | NO | NO | Metronidazole regular tablet or capsule | |
| Fluanxol® tablet | NO | YES | ||
| Fludara® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Flurbiprofen tablet | NO | NO | Crushed sucked or chewed tablets may cause oropharyngeal irritation. | |
| Flutamide (generic) tablet | Yes but See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. Tablet is scored | |
| Fluvoxamine tablet | YES | See comment | Crushed or chewed tablets may cause local irritation. | |
| Fortovase®Roche® capsule | NO | NO | Do not chew capsule | |
| Forxiga tablet | NO | NO | Swallow whole | |
| Fosamax® tablet | NO | NO | Fosamax® oral solution (discontinued in may 2011) | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Fosavance® tablet | NO | NO | Fosamax® oral solution (discontinued in may 2011) and vitamin D oral solution | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Froben® tablet | NO | NO | Mucous membrane irritant. | |
| Froben® SR sustained release tablet (discontinued) | NO | NO | Do not crush or chew the capsule. | |
| Fruzaqla® capsule | NO | NO | Do not open, crush or chew the capsule.Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Fucidin® tablet | YES | YES See comment | Taste may be unacceptable to patient. | |
| Galafold® capsule | NO | NO | Swallow whole capsule. Do not open chew nor crush | |
| Galexos® capsule | NO | NO | Swallow whole capsule, do not open. | |
| Gemfibrozil (generic) tablet | Prefer alternative | See comment | Lopid® or generic capsule 300mg | Taste may be unacceptable to patient. |
| Gentlax® et Gentlax®'S enteric-coated tablet | NO | NO | Active ingredient (bisacodyl)inactivated by gastric acidity | |
| Giotrif® tablet | NO | NO | Swallow whole. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Gleevec® tablet | YES | NO | Antineoplastic. Take precautions applied to cytostatic drugs. May be dissolved in water or apple juice (50ml for 100mg and 200ml for 400mg tablet. Drink immediately. | |
| Glumetza® extended-release tablet | NO | NO | Glucophage® (metformine) regular tablet (BID) | |
| Grastek® sublingual tablet | NO | NO | ||
| Holkira Pak® (combinaison of tablets) | NO | NO | ||
| Hydrea® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Skin and mucous membrane irritant. | |
| Hydromorph Contin® extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with soft and cool food. Do not chew granules - risk of serious overdose. | |
| Hydroxychloroquine (generic) tablet | YES See comment | See comment | Compound hydroxychloroquine 25mg/ml. | |
| Hydroxyurea (generic) capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Skin and mucous membrane irritant. | |
| Hydroxyzine (generic) capsule | NO | Prefer alternative | Atarax®or generic syrup 10mg/5ml. | Taste may be unacceptable to patient. |
| Hyzaar® tablet | NO See comment | YES See comment | If tablet divided unequal dose of hydrochlorothiazide. Bad taste if crushed. | |
| Ibrance® capsule | NO | NO | Swallow whole. Do not open, crush or chew capsule. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Ibsrela® tablet | See comment | NO | Do not chew or crush. | |
| Ibuprofène (generic) tablet | See comment | See comment | Prefer Advil® or Motrin® in oral suspension or chewable tablets. | Taste may be unacceptable to patient. |
| Idhifa® tablet | NO | NO | Antineoplastic. Do not cut chew or crush tablet. | |
| Imatinib (generic) tablet | NO | See comment | NO | Antineoplastic. Take precautions applied to cytostatic drugs. May be dissolved in water or apple juice (50ml for 100mg and 200ml for 400mg tablet. Drink immediately. |
| Imbruvica® capsule | NO | NO | Swallow whole do not alter capsule. | |
| Imdur® extended-release tablet | YES (in two) | NO | Do not chew or crush | |
| Imipramine (generic) tablet | NO | See comment | Taste may be unacceptable to patient. | |
| Imitrex DF ® tablet | NO | NO | Imitrex® nasal spray. Compound of sumatriptan 5mg/ml | Do not alter tablet. Bad taste. |
| Imodium® Quick dissolve tablet | NO | NO | Dissolves on tongue | |
| Imuran® tablet | YES See comment | YES See comment | Compound of azathioprine lOmg/ml and 50mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Incivek® tablet | See comment | See comment | Taste may be unacceptable to patient. | |
| Inderal®-LA extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing. | |
| Inqovi® tablet | NO | NO | Swallow whole. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Inlyta® tablet | NO | NO | Swallow whole do not alter tablet. | |
| Inrebic® capsule | NO | NO | Swallow whole. Do not open, crush or chew capsule. | |
| Intelence® tablet | YES | NO | Tablet can be dissolved in a glass of water. Drink immediately, rince glass with water and drink content. | |
| Intuniv XR® extended-release tablet | NO | NO | Do not alter tablet. | |
| Invega® extended-release tablet | NO | NO | Osmotic tablet. Do not alter. | |
| Invirase® capsule | See Comment | See Comment | Compound of saquinavir 50mg/ml | Capsule may be opened. |
| Invokana® tablet | NO | NO | Do not alter tablet. | |
| Ionamin® capsule | NO | NO | Cationic exchange resin complex | |
| Iressa® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Iron sulfate ou fumarate tablets ou capsules or extended release | NO | NO | Commercial liquid formulations available (sulfate ou fumarate) | Swallow whole do not cut open chew or crush. |
| ISDN isosorbide dinitrate tablet (generic) | YES | NO | Theoretical explosion risk if pulverised. | |
| ISDN isosorbide dinitrate sublingual tablet (generic) | NO | NO | Dissolves under tongue | |
| ISMN isosorbide-5 monoitrate extended-release tablet (generic) | YES in two | NO | Do not chew | |
| Isoptin ®SR extended-release tablet | See comment | NO | Compound of verapamil 50mg/ml | 180mg and 240 mg tablets are scored. |
| Itulatek® sublingual tablet | NO | NO | Sublingual tablet | |
| Jakavi® tablet | NO | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. Compound for nasogastric use: Dissolve 1 tablet in 40ml of water and mix for 10 minutes. Use within 6 hours | |
| Jalyn® modified-release capsule | NO | NO | Do not open chew or crush. Teratogenic and may be absorbed by skin. Women and children should not manipulate capsule. Mucous membrane irritant. | |
| Janumet XR® extended-release tablet | NO | NO | Januvia® (or generic)and Metformine | |
| Jukstapid® capsule | NO | NO | Do not open chew or crush capsule. | |
| Juluca® tablet | YES | See comment | Bioavailability of rilpivirine can decrease up to 50% if tablet is crushed. | |
| K-Dur® sustained release tablet | YES (in two) | NO | Tablet may be dissolved in 115ml of water for 2-3 minutes. Mix 30 seconds and drink content without chewing pellets. | |
| Kadian® extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with soft and cool food (yogurt or jam). Do not chew granules - risk of serious overdose. | |
| Kaletra® film-coated tablet and soft gel capsule | NO | NO | Kaletra® solution 80mg +20mg/ml | |
| Kazano® tablet | NO | NO | Do not cut crush or chew | |
| Keppra® tablet | YES | YES See comment | Tablet can be modified if patient accepts taste. Coating masks bad taste. | |
| Kerendia® tablet | NO | YES See comment | Tablet may be crushed and mixed with water or soft food. Administer the mix immediately. | |
| Ketek® film-coated tablet | See comment | See comment | Taste may be unacceptable to patient. Bitter taste. | |
| Ketoprofen E (generic) enteric-coated tablet | NO | NO | Ketoprofene capsule 50 mg (generic) or suppository 100mg | |
| Ketoprofen SR (generic) sustained-release tablet | NO | NO | Ketoprofene capsule 50 mg (generic) or suppository 100mg | |
| Kisqali® tablet | Swallow whole. Do not take if tablet altered. Antineoplastic. Take precautions applied to cytostatic drugs. | |||
| Kivexa® tablet | See comment | NO | 3TC® 50mg/5ml oral liquid + Ziagen® 100mg/5ml oral liquide | Do not chew tablet |
| Koselugo® capsule | NO | NO | Swallow whole. Do not open chew or modify capsule. | |
| Lanvis® tablet | See comment | See comment | Thioguanine 20mg/ml compound | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Lariam® tablet | YES | See comment | Bitter taste. | |
| Leflunomide (generic) tablet | See comment | See comment | Swallow whole. Manipulate with caution. Immunomodulator. | |
| Lenvima® capsule | NO | NO | Swallow whole. Do not open chew or modify capsule. | |
| Lescol®XL extended-release tablet | NO | NO | Lescol® 40 mg capsules BID | |
| Leukeran® tablet | NO | NO | Chlorambucil 2mg/ml compound. | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Levaquin® tablet | See comment | See comment | Levofloxacine 50mg/ml compound | Taste may be unacceptable to patient. Do not chew. Coating masks taste. |
| Levodopa-carbidopa CR (generic) controlled release tablet | Voir remarque | NO | Levodopa-carbidopa regular tablet. Compound of levodopa 5mg/ml+ carbidopa 1.25mg/ml | The CR 200/50 tablet is scored. |
| Litfulo® capsule | NO | NO | ||
| Lithium carbonate SR extended-release tablet (generic) Discontinued | YES | NO | Carbolith® capsule or generic. Lithium citrate 300mg/5ml (Pms®) syrup | |
| Lonsurf® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Lopid® tablet | Prefer alternative | See comment | Lopid® or generic capsule 300mg | Taste may be unacceptable to patient. |
| Lopresor®SR slow release tablet | NO | NO | Lopresor® regular tablet or generic. Compound of metoprolol 10mg/ml. | |
| Lorbrena® tablet | NO | NO | Antineoplastic. Do not chew cut or crush tablet. | |
| Losec® delayed release tablet | NO | NO | Losec® capsule or generic. Compound of omeprazole 2mg/ml | Active ingredient is inactivated by gastric acidity. |
| Losec® delayed release tablet capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce | |
| Lumakras® tablet | NO | See comment | Swallow whole. Do not cut, crush or chew. Tablet may be dissolved in 120ml of water and administered within 2 hours. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Luvox® tablet | YES | See comment | May cause local irritation if crushed or chewed. | |
| Lunesta® tablet | NO | NO | Swallow whole. Do not cut chew nor crush. | |
| Lynparza® capsule | NO | NO | Do not open, crush or chew or dissolve capsule. | |
| Lysodren® tablet | See comment | See comment | Tablet is scored. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| M-Eslon® extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with soft food or liquid. | |
| M.O.S.-SR® slow release tablet | NO | NO | M-Eslon® capsule. | Danger of severe overdose if crushed or chewed. |
| Macrobid® macrocrystals capsule | NO | NO | Nitrofurantoin regular tablet 50 or 100mg. Compound of nitrofurantoin 10mg/ml. | Do not open capsule. 25% of dose is slow release as macrocrystals. |
| Mar-trientine® capsule | NO | NO | Do not open, crush or chew, risk of contact dermatitis (skin). | |
| Matulane® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Mavenclad® tablet | NO | NO | Antineoplastic. Swallow whole tablet immediatly after removing from blister. | |
| Maviret® tablet | NO | NO | Swallow whole. Do not cut chew nor crush. | |
| Maxalt RPD® Rapid dissolving tablet or wafer | NO | NO | Dissolves when placed on tongue. | |
| Mefloquine (generic) tablet | YES | See comment | Bitter taste | |
| Mesasal® enteric-coated tablet | NO | NO | Dissolves in terminal ileum and colon. | |
| Mestinon® tablet | YES | NO | Hygroscopic | |
| Mestinon®-SR slow release tablet | YES | NO | Matrix tablet | |
| Methotrexate tablet | See comment | See comment | Methotrexate 2.5mg/ml compound | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Methotrimeprazine (generic) tablet | Prefer alternative | Prefer alternative | Nozinan® oral solution 25mg/5ml | Very light-sensitive active ingredient. |
| Methylphenidate SR (generic) slow release tablet | NO | NO | Ritalin® regular tablet or Biphentin® controlled release capsule. | |
| Metoprolol SR (generic) slow release tablet | NO | NO | Lopresor® regular tablet or generic | |
| Mezavant® delayed and extended-release tablet | NO | NO | Dissolves in the entire colon. | |
| Micro-K extentabs MD controlled release tablet | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with soft food . | |
| Mictoryl® modified-release capsule | NO | NO | Do not chew or crush capsule. No available data for capsule opening. | |
| MirtazapineOD (generic) orally disintegrating tablet | NO | NO | Dissolves on tongue | |
| Morphine sulfate SR (generic) slow release tablet | NO | NO | M-Eslon® capsule | Breaking chewing or crushing the tablet can release a potentielly fatal morphine dose. |
| Motrin® IB tablet | See comment | See comment | Prefer oral suspension or chewable tablets. | Bad taste. |
| MS Contin® sustained release tablet | See comment | NO | M-Eslon® capsule. | Only the 200mg tablet may de divided in 2. Breaking chewing or crushing the tablet can release a potentielly fatal morphine dose. |
| Mucinex® extended-release bi-layer tablet | NO | NO | ||
| Mycophenolate Mofetil (generic) capsule and tablet | NO | NO | Cellcept® oral suspension 200mg/ml | Immunosuppressant. carcinogenic potential if contact with skin or inhaled. Take precautions applied to cytostatic drugs. |
| Myfortic® enteric-coated tablet | NO | NO | Cellcept® oral suspension 200mg/ml. Take note: 180mg Myfortic® = 250mg Cellcept®. | Enteric-coated do not modify tablet. Immunosuppressant with carcinogenic potential if contact with skin or inhaled. Take precautions applied to cytostatic drugs. |
| Myleran® tablet | See comment | See comment | Compound of busulfan 2mg/5ml | Antineoplastic. Take precautions applied to cytostatic drugs. |
| Myrbetriq® extended-release tablet | NO | NO | ||
| Naprelan® controlled release tablet | NO | NO | Naprosyn® oral suspension 125mg/5ml or 500mg suppository | |
| Naprosyn® E enteric-coated tablet | NO | NO | Naprosyn® oral suspension 125mg/5ml or 500mg suppository | |
| Naprosyn® SR sustained release tablet | NO | NO | Naprosyn® oral suspension 125mg/5ml or 500mg suppository | |
| Naproxen EC (generic) enteric-coated tablet | NO | NO | Naprosyn® oral suspension 125mg/5ml or 500mg suppository | |
| Naproxen SR (generic) sustained release tablet | NO | NO | Naprosyn® oral suspension 125mg/5ml or 500mg suppository | |
| Nerlynx® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Neoral® capsule | NO | NO | Neoral® oral solution. | Immunosuppressant. Take precautions applied to cytostatic drugs. |
| Nesina® tablet | NO | NO | Do not cut crush or chew. | |
| Neurontin® tablet | YES prefer alternative | See alternative | Use Neurontin® capsule 100mg, 300mg and 400mg. Compound of gabapentine 100mg/ml. | Hard coating (tablet). Capsule may be opened and the content mixed with orange juice or applesauce. |
| Nexavar® tablet | YES See comment | NO | Dissolve in water without crushing. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Nexium® enteric-coated tablet | NO | NO | Nexium® sachet 10mg | Dissolve tablet in 125ml of water without crushing. Mix and drink immedialty, do not chew pellets. |
| Ni-Odan® extended-release tablet | NO | NO | Not interchangeable with niacin regular tablets | |
| Niaspan® extended-release tablet | NO | NO | Not interchangeable with niacin regular tablets | |
| Nifedipine PA (generic) prolonged action tablet | NO | NO | Amlodipine (Norvasc®) (Same family) may be crushed. | |
| Nifedipine XL (generic) extended-release osmotic tablet | NO | NO | Amlodipine (Norvasc®) (Same family) may be crushed. | Severe overdose risk if tablet modifyed!! Swallow whole. |
| Ninlaro® capsule | NO | NO | Swallow whole. Do not open capsule. | |
| Nitrostat® sublingual tablet | NO | NO | Theoretical risk of explosion if crushed | |
| Nocdurna® sublingual tablet | NO | NO | Do not cut crush or chew.. Sublingual tablet. | |
| Nolvadex®-D tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Norflex® extended-release tablet | NO | NO | ||
| Norfloxacine (generic) tablet | YES | See comment | Taste may be unacceptable to patient. | |
| Norpramin® tablet | NO | See comment | Taste may be unacceptable to patient. | |
| Norvir® capsule | NO | Prefer alternative | Norvir® oral solution 400mg/5ml or tablet | |
| Novasen® enteric-coated tablet | NO | NO | ASA 325 mg tablet ou ASA 80mg chewable tablet. | |
| Nozinan® tablet | Prefer alternative | Prefer alternative | Nozinan® oral solution 25mg/5ml | Very light-sensitive active ingredient. |
| Nubeqa ® tablet | See comment | NO | Swallow whole. Do not cut, crush or chew. | |
| Nucynta® CR controlled release tablet | NO | NO | Severe overdose risk if tablet modifyed!! Swallow whole. | |
| Odomzo ® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not open crush dissolve or chew capsule. | |
| Ofev® capsule | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Ojjaara® tablet | NO | NO | Swallow whole. Do not cut, crush, chew or dissolve.Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Olanzapine ODT (generic) tablet | NO | NO | Dissolves on tongue. May be dissolved in 125ml of water, milk, coffee, orange juice, apple juice. Drink immediately. | |
| Olex® delayed release tablet | NO | NO | Losec® capsule or generic. Compound of omeprazole 2mg/ml | Active ingredient is inactivated by gastric acidity. |
| Omeprazole (generic) delayed release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce | |
| Omeprazole (generic) delayed release tablet | NO | NO | Losec® capsule or generic. Compound of omeprazole 2mg/ml | Active ingredient is inactivated by gastric acidity. |
| Ondansetron ODT (generic) tablet | NO | NO | Dissolves on tongue | |
| One-Alpha® capsule | NO | Prefer alternative | One-Alpha® oral drops 2 mcg/ml | |
| Onureg® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Opsumit® tablet | NO | NO | Swallow whole. Take precautions applied to cytostatic drugs. | |
| Opsynvi® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Oralair® sublingual tablet | NO | NO | Sublingual tablet, do not modify. | |
| Orfadin® capsule | See comment | See comment | Capsules may be opened and the contents suspended in a small amount of water or formula immediately before intake. | |
| Orgovyx® comprimé | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Orkambi® tablet | NO | NO | Swallow whole. Do not cut, crush, dissolve or chew. | |
| Orphenadrine (generic) extended-release tablet | NO | NO | ||
| Osphena® tablet | YES See comment | YES See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Ostac® capsule | NO | NO | Crushed sucked or chewed tablets may cause oropharyngeal irritation. | |
| Otezla tablet | NO | NO | Swallow whole tablet. | |
| Oxycontin® Oxyneo® controlled release tablet | NO | NO | Oxycodone regular tablet (Supeudol® etc.) | Breaking chewing or crushing the tablet can release a potentielly fatal oxycodone dose. Oxyneo®formulation is hard to cut or crush and has hydrogelling properties. |
| Pancrease®, Pancrease® MT delayed capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing. mixed with applesauce or acidic baby food or Jello®. Avoid mixing with dairy products. | |
| Pantoloc® enteric-coated tablet | NO | NO | Compound of pantoprazole 2 mg/ml. Prevacid® FasTab, omeprazole capsule or Dexilant® capsule | Active ingredient is inactivated by gastric acidity. |
| Pantoprazole (generic) enteric-coated tablet | NO | NO | Compound of pantoprazole 2 mg/ml. Prevacid® FasTab, omeprazole capsule or Dexilant® capsule | Active ingredient is inactivated by gastric acidity. |
| Pariet® enteric-coated tablet | NO | NO | Prevacid® FasTab, omeprazole capsule or Dexilant® capsule | Active ingredient is inactivated by gastric acidity. |
| Paxil® CR controlled release tablet | NO | NO | Paxil® tablet | Matrix tablet with enteric-coating. |
| Paxlovid® tablets | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| PCE® enteric-coated tablet | NO | NO | Eryc® capsule | |
| Pemazyre® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Pentasa® extended-release tablet | YES | NO | Enteric-coated micro-pellets. Active ingredients released in small intestine and colon. Tablet may be disolved in 50ml of water. Drink immedialtly without chewing pellets. | |
| Pentoxifylline SR (generic) slow release tablet | NO | NO | Compound of pentoxifylline 20mg/ml suspension | Increase of side effects if divided. |
| Periostat® capsule | NO | NO | Compound of doxycycline 5mg/ml. | May cause oropharyngeal irritation if capsule opened. |
| PhosLo® tablet | NO | NO | Dissolves in proximal small intestine. | |
| Phosphate-Novartis® effervescent tablet | YES | NO | Has to be dissolved in water. | |
| Phyllocontin® et Phyllocontin350® extended-release tablet | YES In | NO | ||
| Piqray® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Piroxicam (generic) capsule | NO | NO | Piroxicam suppository 20mg | May cause oropharyngeal irritation, swallow whole. |
| Plaquenil® tablet | YES | See comment | Compound of hydroxychloroquine 25mg/ml. | Gastrointestinal intolerance if tablet crushed |
| Plendil® extended-release tablet | NO | NO | Other calcium channel blocker such as Norvasc® | |
| Pomalyst® capsule | NO | NO | Do not open capsule. Take precautions applied to cytostatic drugs. | |
| Ponvory® tablet | NO | NO | Swallow whole. Do not cut crush nor chew. | |
| Posanol® delayed release tablet | NO | NO | Oral suspension 40mg/ml | Active ingredient released in small intestine. Do not cut chew or crush. |
| Potassium (generic) slow release tablet | NO | NO | Micro-K® capsule | |
| Pradaxa® capsule | NO | NO | Swallow whole. Do not open capsule. Bioavailability increased by 75% if capsule opened. | |
| Prazosine (generic) tablet | YES | See comment | Taste may be unacceptable to patient. | |
| Premarin® tablet | NO | NO | Oestrogens topical preparation. Ex: Estrogel®, Estrace® tablet | |
| Premplus® modified release tablet | NO | NO | Valid only for Premarin® tablets in the package. | |
| Prevacid®FasTab delayed release tablet | NO | NO | Dissolves on tongue. Do not chew tablet. | |
| Prevacid® delayed release capsule | NO | NO | Compound of lansoprazole 3mg/ml | Sprinkle content of capsule on applesauce. |
| Prevymis® tablet | NO | NO | Swallow whole. Do not cut crush nor chew. | |
| Prezcobix® tablet | NO | NO | Do not chew cut or crush. | |
| Prezista® tablet | YES | YES | ||
| Pristiq® extended-release tablet | NO | NO | ||
| Procan®SR slow release tablet | See comment | NO | Compound of procainamide 50mg/ml | 500mg and 750 mg tablets are scored. |
| Procysbi® delayed release capsule | NO | See comment | Capsule may be opened and content sprinkled over 125ml of applesauce. (stable 30 minutes). Do not chew on pellets. | |
| Procytox® tablet | See comment | See comment | Compound of cyclophosphamide 5mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. Tablet if difficut to split. |
| Prograf® capsule | NO | See comment | Compound of tacrolimus 0.5mg/ml suspension | Immunosuppressant. Take precautions applied to cytostatic drugs. |
| Propecia® and Proscar® tablets | See comment | See comment | Teratogenic and may be absorbed by skin. Women and children should not manipulate capsule | |
| Purinethol® tablet | See comment | See comment | Compound mercaptopurine 5mg/ml ou 50mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. Tablet is scored |
| Quetiapine XRT (generic) tablet | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Qinlock® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Rabeprazole (generic) enteric-coated tablet | NO | NO | Active ingredient is inactivated by gastric acidity. | |
| Ragwitek® sublingual tablet | NO | NO | Sublingual use | |
| Ralivia® extended-release tablet | NO | NO | Breaking chewing or crushing the tablet can release a potentielly fatal tramadol dose. | |
| Rapaflo® capsule | NO | See comment | Capsule may be opened and the contents taken without crushing and chewing mixed with soft food. | |
| Rapamune® tablet | NO | NO | Rapamune® oral solution | Pharmacokinetik technology NanoCrystal could be compromised if tablet modified. |
| Reactine® complete Sinus + Allergy extended-release tablet | NO | NO | Reactine® tablet and pseudoephedrine 60mg tablet or 30mg/5ml sirup | Two-layer tablet containing immediate release cetirizine and extended-release pseudoephedin. |
| Redoxon® effervescent tablet | See comment | NO | Friable tablet. Has to be dissolved in water. | |
| Remeron®RD orally disintegrating tablet | NO | NO | Dissolves on tongue | |
| Remeron® tablet | YES | NO | Remeron® RD | Prefer alternative |
| Reminyl® ER extended-release capsule | NO | NO | Do not chew on pellets | |
| Renagel® tablet | NO | NO | Compound of Sevelamer 50 mg/ml | Hygroscopic |
| Renedil® extended-release tablet | NO | NO | Other dihydropyridine as Norvasc® tablet. | |
| Renvela® tablet | NO | NO | Hydroscopic | |
| Requip® tablet | YES See comment | YES See comment | Do not chew (taste?). Very light-sensitive tablet. | |
| Rescriptor® tablet | See comment | See comment | Tablet may be dissolved in 90 ml of water. Drink immediately. | |
| Retevmo® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not open crush dissolve or chew capsule. | |
| Revlimid® capsule | NO | NO | Teratogenic potential. Women and children should not manipulate. Do not open or chew capsule. | |
| Reyataz® capsule | NO | See comment | Capsule may be opened and the content mixed with a small quantity of water then added to applesauce, milk or yogurt. The mix has to be administered within one hour. Do not mix with juice or foods with high PH. | |
| Rezurock® tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Rinvoq® extended-release tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Rizatriptan ODT (generic) orally disintegrating tablet | NO | NO | Dissolves when placed on tongue. | |
| Risedronate (generic) tablet | NO | NO | Fosamax® solution oral solution 70mg/75ml (discontinued in may 2011) | Crushed sucked or chewed tablets may cause oropharyngeal irritation. |
| Risperdal® M-Tab orally disintegrating tablet | NO | NO | Dissolves when placed on tongue. | |
| Ritalin® SR slow release tablet | NO | NO | Ritalin® tablet or Biphentin® extended release capsule | |
| Rocaltrol® capsule | NO | Prefer alternative | Rocaltrol® oral solution 1mcg/ml | |
| Rozlytrek® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not open crush dissolve or chew capsule. | |
| Rukobia® extended-release tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Rythmodan®-LA sustained release tablet | YES | NO | Compound of disopyramide lmg/ml or lOmg/ml suspension. Rythmodan® capsule (QID) | |
| Salagen® tablet | NO | NO | Do dot bite or chew | |
| Salazopyrin EN-tabs® enteric-coated tablet | NO | NO | Salazopyrin® tablet (not for same indication) | |
| Salofalk® enteric-coated tablet | NO | NO | Dissolves in distal small intestine and proximal colon. | |
| Saphris® sublingual tablet | NO | NO | Sublingual use | |
| Scemblix® tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Sebivo® tablet | NO | NO | ||
| Selax® capsule | NO | See comment | Colace® oral drops or sirup. | Taste may be unacceptable to patient. |
| Sensipar® tablet | NO | NO | ||
| Seroquel XR® extended-release tablet | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Sinemet® CR controlled release tablet | See comment | NO | Sinemet® regular tablet. Compound of levodopa 5mg/ml + carbidopa 1.25mg/ml | Sinemet® CR 200/50 tablet is scored. Extended release formulation is 25-30% less bioavailable than regular formulation. |
| Slow-K® slow-release tablet | NO | NO | Micro-K® capsule | |
| Soflax® capsule | NO | See comment | Colace® oral drops or sirup. | Taste may be unacceptable to patient. |
| Soriatane® capsule | NO | NO | Swallow whole tablet. Mucous membrane irritant. | |
| Sotyktu® tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Sporanox® capsule | NO | NO | Not interchangeable with Sporanox® oral solution | Do not chew the pellets. Capsule may be opened and content mixed with peanut butter or chocolate. |
| Sprycel® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Matrix tablet. | |
| Stalevo® tablet | NO | NO | Do not divide or crush. Active ingredient can stain oral mucosa. Splitting tablet may result in unequal dosage. | |
| Stivarga® tablet | NO | NO | Swallow whole | |
| Strattera® capsule | NO | NO | Do not open capsule . Skin, eye and mucosa irritant. | |
| Sublinox® sublingual tablet | NO | NO | Sublingual use. | |
| Suboxone® sublingual tablet | NO | NO | Tablet to be held 2-10 minutes under tongue, until complete dissolution. | |
| Sudafed® 12H extended-release tablet | NO | NO | Pseudoephedrine 60 mg tablet or sirup 30 mg/5ml (Pms®). | |
| SulfasalazineEC (generic) enteric-coated tablet | NO | NO | Salazopyrin® tablet (not for same indication) | |
| Sumatriptan (generic) tablet | See comment | See comment | Imitrex® nasal spray. Compound of sumatriptan 5mg/ml | Bad taste if chewed or crushed. |
| Sunosi® tablet | See comment | See comment | The 150mg tablet cannot be divided. The 75mg tablet is scored. | |
| Sustiva® capsule and tablet | NO | See comment | Capsule may be opened and content mixed with small quantity of food or liquid. | |
| Sutent® capsule | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Suvexx® tablet | NO | NO | Swallow whole. Do not chew cut or crush. | |
| Symmetrel® capsule | NO | NO Prefer alternative | Symmetrel® oral solution 50mg/5ml | |
| Symtuza® tablet | NO | NO | Do not cut crush nor chew tablet. Swallow whole. | |
| Tabrecta® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tafinlar® capsule | NO | NO | Do not open or chew capsule. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tagrisso® tablet | NO | NO | Do not cut crush or chew tablet. May be dissolved in 50ml of water. Drink immediately. | |
| Talzenna® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not open crush dissolve or chew capsule. | |
| Tamofen® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tamoxifene (generic) tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tamsulosine (generic) extended-release capsule or tablet | NO | NO | Do not chew or crush pellets in capsule. Do not modify tablet. | |
| Tarceva® tablet | YES See comment | YES See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tarka® extended-release tablet | NO | NO | Mavik® capsule and Isoptin® SR extended-release tablet. | Bi-layer tablet. Immediate release trandolapril and extended release verapamil. |
| Tasigna® capsule | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Opening capsule may increase blood concentration and toxicity. | |
| Tavneos® capsule | NO | NO | Do not open, crush or chew tablet. | |
| Tecfidera® capsule entérique | NO | NO | Do not open, crush or chew capsule. | |
| Tegretol® CR controlled release tablet | YES in two | NO | Tegretol® chewable tablet or oral suspension | |
| Telzir® tablet | Prefer alternative | NO | Telzir® 250mg/5ml oral suspension | |
| Temodal® capsule | See comment | See comment | Do not chew capsule. Avoid powder contact with skin or mucosa. Antineoplastic. Take precautions applied to cytostatic drugs. Content of capsule may be dissolved in juice or applesauce. | |
| Tepmetko® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tetracycline (generic) capsule | NO | NO | Compound of tetracycline 25mg/ml suspension | May stain teeth. Swallow whole. |
| Testosterone (generic) capsule | NO | NO | Androgel® or Androderm® | Do not chew capsule. |
| Théophylline LA (generic) sustained-release tablet | YES in two | NO | Theophylline sirup (Theolair®). Ajust intake frequency. | |
| Tiazac® extended-release capsule | NO | NO | Not equivalent to other formulations of diltiazem | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, |
| Tiazac®XC extended-release tablet | NO | NO | ||
| Tibsovo® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tofranil® tablet | NO | See comment | Taste may be unacceptable to patient. | |
| Topamax® tablet and sprinkle capsule | NO | NO | Topamax® capsule. Compund of topiramate 6mg/ml suspension | Capsule may be opened and the contents taken without crushing and chewing mixed with soft food, Taste may be unacceptable to patient if tablet chewed, |
| Topiramate tablet | NO | NO | Topamax® capsule | Taste may be unacceptable to patient if tablet chewed. |
| Toviaz® tablet | NO | NO | Do not chew cut or crush. | |
| Tracleer® tablet | See comment | Prefer alternative | Dissolve tablet in water. Stable 24 hours. | Teratogenic and may be absorbed by skin. Women and children should not manipulate capsule. |
| Trental® extended-release tablet | NO | NO | Compound of pentoxifylline 20mg/ml suspension (ajust dosage) | Dividing tablet may increase side effects. |
| Tridural® extended-release tablet | NO | NO | Breaking chewing or crushing the tablet can release a potentielly fatal tramadol dose. | |
| Trinalin® bi-layer tatblet | NO | NO | Optimine® plus pseudoephedrine 60mg 60mg tablet or sirup 30mg/5ml (Pms®) | Coating contains 1mg of azatadine and 60 mg of pseudoephedine immediate release and the core contains delayed-release (4-6 hours) pseudoephedrine 60mg. |
| Trulance® tablet | See comment | YES | Tablet may be crushed and mixed with applesauce or dissolved in 30ml of water and taken immediately. | |
| Truqap® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Do not ingest if tablet not intact. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tukysa ® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Tylenol® Arthritis Pain, Tylenol® Muscle&Body extended-release tablet | NO | NO | Tylenol® tablet or chewable tablet | |
| Ultrase® Ultrase®MT enteric-coated capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing. mixed with applesauce or acidic baby food or Jello®. Avoid mixing with dairy products. | |
| Uniphyl® sustained release tablet | YES in two | NO | Theophylline sirup (Theolair®). Ajust intake frequency. | |
| Uptravi® tablet | NO | NO | Swallow whole. Do not cut, crush or chew tablet. | |
| Urispas® film-coated tablet | YES See comment | YES See comment | Hard coating makes splitting difficult. | |
| Urocit-K® extended-release tablet | NO | NO | Coated with wax layer that prevents gastrointestinal irritation. The empty layer may be found in stools (partially or complete). | |
| Uromax® controlled release tablet | NO | NO | Oxybutynin tablet (ajust dosage). Ditropan® sirup 5mg/5ml or Oxytrol® skin patch. | |
| Valcyte® tablet | NO | NO | Compound of valganciclovir 90 mg/ml suspension | Teratogenic and carcinogenic potential Take precautions applied to cytostatic drugs. |
| Valproic acid (generic) capsule | NO | NO | Depakene® or generic liquid suspension | Mucous membrane irritant. Swallow whole. Do not chew. |
| Vancocin® capsule | NO | NO | Do not open capsule. The capsule has a solid content. | |
| Vascepa® capsule | NO | NO | Swallow whole. Do not open, crush, chew or dissolve capsule. | |
| Velphoro® chewable tablet | YES | YES | Has to be chewed or crushed. Do not swallow whole. | |
| Velsipity® tablet | NO | NO | Swallow whole do not chew cut nor crush. | |
| Venclexta® tablet | NO | NO | Swallow whole do not chew cut nor crush | |
| Venlafaxine XR (generic) extended-release capsule | NO | NO | Capsule may be opened and the contents taken without crushing and chewing mixed with applesauce, | |
| Veozah® tablet | NO | NO | Swallow whole do not chew cut nor crush tablet | |
| Vepesid® capsule | NO | NO | Compound of etoposide 10mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. The etoposide solution for injection may be mixed with orange juice or apple juice or lemonade at a maximal concentration of 0.4 mg/ml. MIx is stable for 3 hours. |
| Verapamil SR (generic) sustained release tablet | See comment | NO | Compound of verapamil 50 mg/ml suspension | 180mg and 240mg tablets are scored. |
| Verzenio® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Vesanoid® capsule | See comment | See comment | Teratogenic .Women of childbearing age should not manipulate capsule. | |
| Vibra-tabs® film-coated tablet and capsule | YES See comment | NO | Compound of doxycycline 5mg/ml. | Crushed sucked or chewed tablets may cause oropharyngeal irritation. Administer with 50ml of liquid to avoid irritation of oesophagus. |
| Videx® EC enteric-coated capsule | NO | NO | Not interchangeable with Videx® chewable tablets | |
| Vimovo® enteric-coated tablet | NO | NO | Do not cut or crush. Enteric-coated core of naproxen coated with a esomeprazole layer. | |
| Viramune XR® extended-release tablet | NO | NO | Do not cut crush or chew | |
| Viread® film-coated tablet | YES | YES See comment | Dissolve tablet in 100ml or more of water orange or grape juice. | |
| Vitalux® extended-release tablet, Vitalux®-S, Vitalux® AREDS extended-release tablet | YES | NO | Vitalux® chewable tablet | |
| Vitrakvi® capsule | NO | NO | Oral solution20mg/ml | Antineoplastic. Take precautions applied to cytostatic drugs. Do not open crush or chew capsule. |
| Vivotif® enteric-coated capsule | NO | NO | Typhim® injectable vaccine | Do not open chew or crush capsule |
| Vizimpro® tablet | See comment | NO | Antineoplastic. Do not crush or chew tablet. | |
| Voltaren® enteric-coated tablet | NO | NO | Voltaren® or diclofenac suppository 50mg or 100mg | |
| Voltaren® SR slow release tablet | NO | NO | Voltaren® or diclofenac suppository 50mg or 100mg | |
| Voranigo® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not cut, crush or chew tablet. | |
| Votrient® tablet | NO | NO | Cutting or crushing the tablet increases the risk of exposition to carcinogenic and teratogenic substance. Take precautions applied to cytostatic drugs. | |
| Vyndaqel® capsule | NO | NO | Do not crush open or chew on capsule | |
| Vyvanse® capsule | NO | NO | Capsule may be opened and content dissolved in a glass of water. Drink immediately. | |
| Wakix® tablet | NO | NO | Swallow whole. Do not cut, crush or chew tablet. | |
| Welbutrin®SR, Wellbutrin®XL slow and extended-release tablets | NO | NO | Wellbutrin SR is a matrix tablet, theoretically can be divided in 2 and taken immediately. | |
| Welireg® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not cut, crush or chew tablet. | |
| Xalkori® capsule | NO | NO | Do not crush open or chew on capsule | |
| Xarelto® tablet | See comment | See comment | Modified tablet has to be taken within 4 hours. (stability) | |
| Xatral® extended-release tablet | NO | NO | Matricial layer containing afuzosin between 2 inactive layers. | |
| Xcopri® tablet | NO | NO | Swallow whole. Do not cut, crush or chew tablet. | |
| Xeloda® tablet | See comment | See comment | Antineoplastic. Take precautions applied to cytostatic drugs. | |
| Xospata® tablet | NO | NO | Antineoplastic. Take precautions applied to cytostatic drugs. Do not cut, crush or chew tablet. | |
| Xpovio® tablet | NO | NO | Swallow whole. Do not cut, crush or chew. | |
| Xtandi® capsule | NO | NO | Do not open chew or crush. | |
| Zarontin® capsule | NO | NO | Zarontin® oral solution 250mg/5ml | Capsule may be dissolved in water (gel-like solution) |
| Zavesca® capsule | NO | NO | Swallow whole. Teratogenic potential. | |
| Zaxine® tablet | NO | NO | Do not cut crush or chew. | |
| Zejula® capsule | NO | NO | Carcinogenic and teratogenic. Take precautions applied to cytostatic drugs. Swallow whole capsule. | |
| Zelboraf® tablet | NO | NO | Do not cut crush or chew. | |
| Zeposia® capsule | NO | NO | Do not crush open or chew on capsule | |
| Ziagen® tablet | NO | NO | Ziagen® 100mg/5ml oral solution | |
| Zofran® ODT orally disintegrating tablet | NO | NO | Dissolves on tongue | |
| Zolinza® capsule | NO | NO | Do not open capsule. Skin and mucosa irritant. | |
| Zomig Rapimelt® orally disintegrating tablet | NO | NO | Dissolves on tongue | |
| Zolmitriptan ODT (generic) tablet | NO | NO | Dissolves on tongue | |
| Zyban® extended-release tablet | NO | NO | Matrix tablet, theoretically can be divided in 2 and taken immediately. | |
| Zykadia® capsule | NO | NO | Swallow capsule whole, do not chew, crush or open | |
| Zyprexa® film coated tablet | Prefer alternative | Prefer alternative | Zyprexa® Zydis® | Do not chew (hard coating) Light-sensitive. |
| Zyprexa® Zydis® orally disintegrating tablet | NO | NO | Dissolves on tongue. May be dissolved in 125ml of water, milk, coffee, orange juice, apple juice. Drink immediately. | |
| Zytiga® tablet | See comment | See comment | Take precautions applied to cytostatic drugs. | |
| Zytram XL® extended-release tablet | NO | NO | Breaking chewing or crushing the tablet can release a potentielly fatal tramadol dose. |